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TCIM Research

Salidroside Protects Against Osteoporosis in Ovariectomized Rats by Inhibiting Oxidative Stress and

Yi-Fei Wang, Yue-yue Chang, Xue-meng Zhang et al. | Published on 4/30/2022
Osteoporosis (OP) is characterized as low bone mass, bone microarchitecture breakdown and bone fragility. The increase of oxidative stress could lead to breakdown in the balance of bone formation and resorption which gives rise to OP. Nrf2 is a transcription factor which takes part in oxidative stress and recently was reported that it can regulate the occurrence of OP. Salidroside (SAL) with the efficacies of anti-oxidation, anti-aging and bone-protection is one of the active ingredients in Ligustri Lucidi Fructus, a traditional Chinese medicinal herb. Nevertheless, few studies have explored the potential mechanism of SAL preventing OP development from the perspective of oxidative stress intervention. Read more here.

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